Clinical trial
Tesamorelin and cognition: the between-group result was neutral
An open-label randomized trial compared tesamorelin with standard care for six months in people with HIV and abdominal obesity.
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Clinical trial
TESTS: a larger thymosin alpha 1 trial with a neutral primary result
The phase 3 sepsis trial found no clear evidence of lower 28-day mortality.
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FLOW: kidney outcomes in diabetes and chronic kidney disease
A kidney-outcome trial illustrates the importance of eligibility criteria and composite endpoints.
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GHK-Cu in experimental silicosis: a proposed PRDX6 mechanism
Mouse and macrophage experiments examined oxidative stress, inflammation and fibrosis.
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GHK-Cu liposome analysis with CE-ICP-MS/MS
Capillary electrophoresis coupled to elemental tandem mass spectrometry was used to investigate copper-peptide encapsulation in liposomes.
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Ipamorelin and reproductive signaling in fish
A tilapia experiment measured feeding, testicular development, androgen-receptor expression and circulating hormones after repeated exposure.
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Ipamorelin in ferrets: weight loss and vomiting were different endpoints
Researchers compared two ghrelin-receptor agonists using intestinal tissue and a cisplatin-exposure ferret model.
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MOTS-c and CK2: tissue-specific signaling and a genetic variant
The paper combined biochemical and mouse experiments with human genetic observations.
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MOTS-c in pancreatic cell lines: insulin and glucagon responses differ
An in-vitro investigation explored endocrine-cell responses and reciprocal peptide regulation.
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Peptide stability assays: sample preparation can create apparent loss
Investigators compared precipitation methods, assay media and labels using model peptides in plasma and cell-culture supernatants.
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Semax in chronic stress: positive and neutral behavioral findings
Male rats exposed to unpredictable stress received Semax or another ACTH analog and underwent behavioral and tissue assessments.
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STEP 9: semaglutide, knee pain and the role of weight change
A trial in people with obesity and knee osteoarthritis measured both weight and pain.
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