Clinical trial
REIMAGINE 3: interpreting an add-on combination trial
Adults already receiving basal insulin were randomized to cagrilintide-semaglutide or placebo in a forty-week blinded study.
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190 source-linked study notes. Explore the design, findings and limits behind the headline.
190 study notes Page 4 of 16
Clinical trial
Retatrutide and cardiovascular biomarkers: risk signals are not events
Investigators analyzed cardiovascular risk markers in adults from retatrutide obesity studies with and without diabetes.
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Retatrutide and memory tasks in diabetic rats: partial responses
Male rats with chemically induced diabetes underwent behavioral tasks and brain inflammatory and tissue measurements.
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Retatrutide metabolomics: exploratory biomarkers after phase 2
Fasting samples from two randomized phase 2 trials underwent exploratory lipidomic and metabolomic analyses.
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Salivary thymosins in preterm infants: longitudinal biomarker trajectories
Repeated saliva samples from a small group of preterm infants were analyzed for thymosin forms and oxidation-related changes.
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Semaglutide and decision-making: a secondary trial analysis
Seventy-two participants with major depressive disorder completed a reward-learning task before and after a randomized sixteen-week study.
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Semaglutide delivery enhancers: transport and barrier recovery
Researchers compared three absorption enhancers using intestinal cell layers, rat experiments and selected large-animal formulations.
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SS-31 after spinal injury: separating tissue and behavioral endpoints
A mouse spinal-contusion model was paired with oxidatively stressed PC12 cells to examine movement, tissue injury and mitochondrial markers.
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SS-31 and alpha-synuclein: membrane interaction as a research question
Biophysical membrane assays and neuroblastoma-cell experiments examined alpha-synuclein binding, aggregation and mitochondrial stress.
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SS-31 and ozone injury: a pretreatment model
Mice and airway epithelial cells received antioxidant interventions before acute ozone exposure, followed by inflammatory and signaling measurements.
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Surfactants and peptide aggregation: stabilization is molecule-dependent
Agitation-stress experiments compared surfactant effects on liraglutide, with exploratory work on semaglutide and glucagon.
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Thymosin alpha 1 and microRNA chaperoning after chemotherapy
Patient measurements were combined with dendritic-cell experiments and tumor-bearing mouse models to investigate an immune-signaling mechanism.
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