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Metabolic research

Semaglutide and decision-making: a secondary trial analysis

Seventy-two participants with major depressive disorder completed a reward-learning task before and after a randomized sixteen-week study.

Clinical trialPaper year: 2026Semaglutide

01 / DESIGN

What was studied?

Seventy-two participants with major depressive disorder completed a reward-learning task before and after a randomized sixteen-week study.

02 / FINDINGS

What did the researchers report?

Computational analysis found changes in choosing higher-expected-reward options and repeating previous choices in the semaglutide group.

03 / LIMITS

How should it be interpreted?

Task behavior is not the same endpoint as depression remission or improved daily functioning. This secondary analysis does not establish a psychiatric indication or support self-directed use.

Voltera Peptide editorial reading note. Based on the linked source record. Methods and corrections.

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