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Mitochondrial research

MOTS-c in dialysis: the sample compartment changes the story

A pilot study measured MOTS-c in serum, urine and dialysate from thirty-two stable peritoneal-dialysis patients.

Human physiology studyPaper year: 2026MOTS-c

01 / DESIGN

What was studied?

A pilot study measured MOTS-c in serum, urine and dialysate from thirty-two stable peritoneal-dialysis patients.

02 / FINDINGS

What did the researchers report?

Associations differed by compartment. Urinary levels correlated with both lower oxidative-stress markers and greater arterial stiffness, while dialysate levels showed a different vascular pattern.

03 / LIMITS

How should it be interpreted?

Small observational correlations do not identify cause or indicate that supplementation helps. Renal handling and sampling compartment are important alternative explanations.

Voltera Peptide editorial reading note. Based on the linked source record. Methods and corrections.

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